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SSR 180711 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SSR 180711 hydrochloride图片
CAS NO:446031-79-4
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
SSR 180711 hydrochloride 是一种具有口服活性、选择性和可逆的 α7 乙酰胆碱烟碱受体 (n-AChRs) 部分激动剂。
Cas No.446031-79-4
Canonical SMILESO=C(N1C2CCN(CC2)CC1)OC3=CC=C(Br)C=C3.Cl
分子式C14H17BrN2O2.HCl
分子量361.66
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Partial agonist at α7 nAChR. Enhances episodic memory and reverses MK-801-induced deficits in retention of episodic memory. Increases extracellular dopamine levels in rat prefrontal cortex. Also exhibits antidepressant-like properties.

Jones et al (2014) Effect of α7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats. Psychopharmacology (Berl). 231 673 PMID:24057763 |Pichat et al (2007) SSR180711, a novel selective α7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology 32 17 PMID:16936709