| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Canonical SMILES | O=S(NC1=NC(NC)=NC(NC)=C1)(C2=CC=C(C=C2)N)=O.Cl.Cl.O |
| 分子式 | C12H16N6O2S·2HCl [XH2O] |
| 分子量 | 381.3 |
| 溶解度 | DMSO: 15 mg/ml,Water: 5 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ro 04-6790 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6(Ki= 44.7 nM).1It is selective for 5-HT6receptors over a panel of 23 additional receptors at 10 µM. Ro 04-6790 inhibits 5-HT-induced cAMP production in HeLa cells expressing human 5-HT6(pA2= 6.75).In vivo, Ro 04-6790 (10 and 30 mg/kg) induces stretching and yawning behavior in rats. It reverses scopolamine-induced decreases in novel object discrimination in rats.2Ro 04-6790 (3, 10, and 30 mg/kg) also attenuates cue-induced cocaine-seeking behavior in rats.3 1.Sleight, A.J., Boess, F.G., BÖs, M., et al.Characterization of Ro 04-6790 and Ro 63-0563: Potent and selective antagonists at human and rat 5-HT6 receptorsBr. J. Pharmacol.124(3)556-562(1998) 2.Woolley, M.L., Marsden, C.A., Sleight, A.J., et al.Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790Psychopharmacology (Berl)170(4)358-367(2003) |
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