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Mebicar
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mebicar图片
CAS NO:10095-06-4
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
Tetramethylglycerol (Tetramethylglycoluril) 是一种作用于 GABA 受体的小分子,具有抗焦虑活性。
Cas No.10095-06-4
别名2,4,6,8-四氮杂双环[3.3.0]辛烷-3,7-二酮,2,4,6,8-四甲基-,Tetramethylglycoluril; Mebicar
Canonical SMILESO=C1N(C2N(C)C(N(C2N1C)C)=O)C
分子式C8H14N4O2
分子量198.2
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Mebicar is an anxiolytic with antiepileptic activity.1,2In vivo, mebicar (10 mg/kg) reduces anxiety-like behavior and decreases stress-induced increases in serum corticosterone and pro-inflammatory cytokine levels in a mouse model of intermittent unpredictable stress.1It inhibits epileptic activity in a rat model of penicillin-induced focal epilepsy.2

1.Kim, C.Y., Kim, Y.G., Sin, S.J., et al.Preventive effect of mebicar and ginsenoside Rg1 on neurobehavioral and immunological disruptions caused by intermittent unpredictable stress in miceNeuroImmunoModulation25(1)49-58(2018) 2.Rekhtman, M.B., Torshin, V.I., and Darinski?, N.V.Effect of mebikar on focal epileptic activityBiull. Eksp. Biol. Med.91(2)178-181(1981)