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5'-chloro-5'-Deoxyadenosine(hydrate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
5'-chloro-5'-Deoxyadenosine(hydrate)图片
CAS NO:698999-09-6
包装与价格：
包装价格(元)
250mg电议
500mg电议
1g电议
5g电议

产品介绍
Cas No.698999-09-6
别名5`-氯-5`-脱氧鸟苷水合物
化学名5'-chloro-5'-deoxy-adenosine, hydrate
Canonical SMILESO[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C32)O[C@@H]1CCl.O
分子式C10H12ClN5O3.XH2O
分子量285.7
溶解度DMF: 30 mg/ml,DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml,DMSO: 25 mg/ml,Ethanol: 0.5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

5'-chloro-5'-Deoxyadenosine (hydrate) is a nucleoside analog used as a substrate in polyketide biosynthesis. S-(5'-adenosyl)-L-methionine can be converted to 5'-chloro-5'-deoxyadenosine in a reaction catalyzed by a SAM-dependent chlorinase. Through a 7-step route, 5'-chloro-5'-deoxyadenosine can be converted to chloroethylmalonyl-CoA, which has been shown to be involved in the biosynthesis of the anticancer agent salinosporamide A in the marine bacterium S. tropica.

References:
[1]1. Eustáquio, A.S., McGlinchey, R.P., Liu, Y., et al. Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine Proc. Natl. Acad. Sci. USA 106(30), 12295-12300 (2009).