MAGL Inhibitor Compound 23 是一种有效的、选择性的、可逆的和竞争性的 MAGL 抑制剂，IC50 为 80 nM。 MAGL Inhibitor Compound 23 对人乳腺癌、结肠直肠癌和卵巢癌细胞具有抗增殖作用。 MAGL Inhibitor Compound 23 在基于细胞的试验和体内试验中阻断 MAGL。
| Cas No. | 2324160-91-8 |
| Canonical SMILES | CC(C)C1=CC=C(C(C2CCN(C(C3=CC(O)=CC=C3F)=O)CC2)=O)C=C1 |
| 分子式 | C22H24FNO3 |
| 分子量 | 369.4 |
| 溶解度 | DMF: 25 mg/ml,DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml,DMSO: 20 mg/ml,Ethanol: 2.5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | MAGL inhibitor compound 23 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 80 nM). It is selective for MAGL over cannabinoid receptor 1 (CB1), CB2, fatty acid amide hydrolase (FAAH), α/β-hydrolase domain-containing protein 6 (ABHD6), and ABHD12 (IC50s = >10 μM). MAGL inhibitor compound 23 inhibits the growth of HCT116, MDA-MB-231, Caov-3, OVCAR-3, and SKOV3 cells (IC50s = 21, 7.9, 25, 57, and 15 μM, respectively) but not MRC5 cells (IC50 = >100 μM). It increases the levels of 2-arachidonoyl glycerol in mouse brain and plasma when administered at a dose of 50 mg/kg. |
m.cnreagent.com