| CAS NO: | 23205-42-7 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 23205-42-7 |
| 别名 | 4-羟基-1-Β-D-呋喃核糖苷-2(1H)吡啶酮,NSC 126849 |
| 化学名 | 4-hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone |
| Canonical SMILES | O=C(C=C(O)C=C1)N1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2 |
| 分子式 | C10H13NO6 |
| 分子量 | 243.2 |
| 溶解度 | 10mg/mL in DMSO, 16mg/mL in DMF |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 3-Deazauridine is a nucleoside analog. [1] It is converted intracellularly to 3-deazauridine triphosphate, which competitively inhibits cytidine triphosphate synthetase thereby inhibiting biosynthesis of the nucleic acid cytidine 5’-triphosphate (CTP). 3-Deazauridine inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM and dose-dependently reduces mortality in a mouse model of leukemia.[2] It also enhances the incorporation of decitabine into DNA in HL-60 myeloid and MOLT-3 lymphoid leukemia cells when used at a concentration of 20 µM. 3-Deazauridine (100 or 150 mg/kg), when combined with decitabine, reduces mortality in an L1210 leukemia mouse model.[3] Reference: |
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