双(甲硫基)胶霉毒素是侵袭性曲霉病的一种比胶霉毒素更稳定可靠的标志物，适用于诊断。
| Cas No. | 74149-38-5 |
| 别名 | 二(甲硫基)焦霉毒素,Bisdethiobis(methylthio)gliotoxin; FR 49175; Dimethylgliotoxin |
| Canonical SMILES | O=C1N(C)[C@](CO)(SC)C(N2[C@]3([H])[C@@H](O)C=CC=C3C[C@]21SC)=O |
| 分子式 | C15H20N2O4S2 |
| 分子量 | 356.5 |
| 溶解度 | DMSO: 25 mg/ml,Ethanol: 25 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 µM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC50s = >400 µM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC50 = 23.56 µM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD50 = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis. |
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