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AZD2423
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZD2423图片
CAS NO:1229603-37-5
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
AZD2423是一种有效的、选择性的、口服生物利用的、非竞争性的CCR2趋化因子受体负向变构调节剂。AZD2423对CCR2Ca2+通量的IC50为1.2nM。
Cas No.1229603-37-5
Canonical SMILESO=C(N1CCN(C([C@@H]2NCCN(C(C)(C)C)C2)=O)CC1)NC3=CC=C(Cl)C(F)=C3
分子式C20H29ClFN5O2
分子量425.93
溶解度DMSO: 200 mg/mL (469.56 mM)
储存条件4℃, stored under nitroge
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca2+ flux [1][2][3].

AZD2423 inhibits MCP-1 induced calcium mobilization and chemotaxis of THP-1 cell line with an IC50 of 4 nM[1].

[1]. AZD2423. [2]. John G. Cumming. CCR2 antagonists for the treatment of neuropathic pain: The discovery and development of AZD2423. [3]. KalliomÄki J, et al. A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia. Pain. 2013 May;154(5):761-7.