| CAS NO: | 1217819-83-4 |
| 包装: | 1mg |
| 市场价: | 5519元 |
| Cas No. | 1217819-83-4 |
| Canonical SMILES | [O-]C([C@@H]1C[C@@](CN1C(C[P@](O[C@@H](C(C)C)OC(CC)=O)(CCCC([2H])([2H])C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O)=O)([H])C3CCCCC3)=O.[Na+] |
| 分子式 | C30H38D7NO7P.Na |
| 分子量 | 592.7 |
| 溶解度 | Acetonitrile:Methanol (1:1): Soluble,DMSO: Soluble,Water: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Fosinopril-d7is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme (ACE) inhibitor fosinoprilat.1Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril (2.5 mg/kg) reduces fractional shortening and decreases left ventricular size in a porcine model of congestive heart failure.2Formulations containing fosinopril have been used in the treatment of hypertension and congestive heart failure. 1.DeForrest, J.M., Waldron, T.L., Harvey, C., et al.Fosinopril, a phosphinic acid inhibitor of angiotensin I converting enzyme: In vitro and preclinical in vivo pharmacologyJ. Cardiovasc. Pharmacol.14(5)730-736(1989) 2.McElmurray, J.H., III, Mukherjee, R., New, R.B., et al.Angiotensin-converting enzyme and matrix metalloproteinase inhibition with developing heart failure: Comparative effects on left ventricular function and geometryJ. Pharmacol. Exp. Ther.291(2)799-811(1999) |
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