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Swinholide A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Swinholide A图片
CAS NO:95927-67-6
包装与价格：
包装价格(元)
10μg电议
50μg电议

产品介绍
Swinholide A 是与肌动蛋白结合的海洋聚酮化合物，可将肌动蛋白二聚化，Kd 约为 50 nM。
Cas No.95927-67-6
化学名(1R,3S,5E,7E,11S,12S,13R,15S,16S,17S,19S,23R,25S,27E,29E,33S,34S,35R,37S,38S,39S,41S)-3,13,15,25,35,37-hexahydroxy-11,33-bis[(1S,2S,3S)-2-hydroxy-1,3-dimethyl-5-[(2S,4R,6S)-tetrahydro-4-methoxy-6-methyl-2H-pyran-2-yl]pentyl]-17,39-dimethoxy-6,12,16,28,34,38-hexamethyl-10,32,45,46-tetraoxatricyclo[39.3.1.119,23]hexatetraconta-5,7,21,27,29,43-hexaene-9,31-dione
Canonical SMILESC[C@@H]([C@H]([C@H](CC[C@@H]1O[C@H](C[C@@H](OC)C1)C)C)O)C([C@@H](C)[C@H](O)C[C@H](O)[C@H](C)[C@@H](OC)C[C@]2(O[C@@]([H])(C=CC2)C[C@@H](O)C/C=C(C)/C=C/C(OC([C@H]3C)[C@H]([C@H]([C@H](CC[C@@H]4O[C@H](C[C@@H](OC)C4)C)C)O)C)=O)[H])OC(/C=C/C(C)=C/C[C@H](O)
分子式C78H132O20
分子量1389.9
溶解度Soluble in methanol, ethanol, DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Swinholide A is a natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells. [1] [2] It stabilizes actin dimers and also binds to and severs F-actin filaments.[1] [3] Swinholide A binds to G-actin in a 1:2 molar ratio and decreases the rate of nucleotide exchange in G-actin. [2]

Reference:
[1]. Bubb, M.R., Spector, I., Bershadsky, A.D., et al. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. The Journal of Biological Chemisty 270(8), 3463-3466 (1995).
[2]. Saito, S.y., Watabem, S., Ozaki, H., et al. Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A. Journal of Biochemistry 123(4), 571-578 (1998).
[3]. Terry, D.R., Higa, T., and Bubb, M.R. Misakinolide A is a marine macrolide that caps but does not sever filamentous actin. The Journal of Biological Chemisty 272(12), 7841-7845 (1997)