Tosyl Phenylalanyl Chloromethyl Ketone (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-Tosyl Phenylalanyl Chloromethyl Ketone) 是一种有效的丝氨酸蛋白酶抑制剂，可与 HPV-18 E7 蛋白的视网膜母细胞瘤蛋白 (RB) 结合核心反应并消除它的RB结合能力。
| Cas No. | 402-71-1 |
| 别名 | L-1,4'-甲基磺酰基-2-苯基乙基氯甲基酮,L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK |
| Canonical SMILES | CC1=CC=C(S(N[C@H](C(CCl)=O)CC2=CC=CC=C2)(=O)=O)C=C1 |
| 分子式 | C17H18ClNO3S |
| 分子量 | 351.8 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tosyl phenylalanyl chloromethyl ketone (TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that has been shown to affect cell proliferation, apoptosis, and tumorigenesis. It can disrupt PDK1 signaling to the AGC kinases, Akt, S6K1, and RSK, as well as MSK1 and MSK2. TPCK also inhibits superoxide production and suppresses neutrophil respiratory burst. |
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