Z-IETD-AFC 是一种特异性荧光底物，可用于确定 caspase-8 的催化活性。
| Cas No. | 219138-02-0 |
| 别名 | Z-异亮氨酰-谷氨酰-苏氨酰-天冬氨酸-AFC |
| Canonical SMILES | OC(C[C@H](NC([C@](NC([C@@H](NC([C@@]([C@@H](C)CC)([H])NC(OCC1=CC=CC=C1)=O)=O)CCC(O)=O)=O)([H])[C@@H](C)O)=O)C(NC(C=C2O3)=CC=C2C(C(F)(F)F)=CC3=O)=O)=O |
| 分子式 | C37H42F3N5O13 |
| 分子量 | 821.8 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Z-IETD-AFC is a fluorogenic substrate for caspase-8 and granzyme B. Upon enzymatic cleavage by caspase-8 or granzyme B, 7-amino-4-trifluoromethylcoumarin (AFC) is released and its fluorescence can be used to quantify caspase-8 or granzyme B activity. AFC displays excitation/emission maxima of 380/500 nm, respectively. |
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