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Taccalonolide AJ
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Taccalonolide AJ图片
CAS NO:1349904-82-0
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Taccalonolide AJ 是一种具有细胞微管稳定活性的半合成化合物。Taccalonolide AJ 对癌细胞具有高效的抗增殖活性,对 HeLa 细胞作用的 IC50 值为 4.2 nM。
Cas No.1349904-82-0
别名根薯酮内酯AJ
Canonical SMILESC[C@]1([C@@]2(O)C)[C@]3(OC2=O)[C@H]([C@@H](C)[C@@]4([H])[C@@]1([H])[C@@H]([C@]5([H])[C@@]4([C@H]([C@@H](OC(C)=O)[C@@]6([H])[C@@]5([H])[C@H](C([C@]7([H])[C@@]6([C@H]([C@@H](O8)[C@@H]8C7)OC(C)=O)C)=O)O)OC(C)=O)C)O)O3
分子式C34H44O14
分子量676.7
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Taccalonolide AJ is a semi-synthesis compound with cellular microtubule stabilizing activity. Taccalonolide AJ exhibits high potency antiproliferative activity against cancer cells, with an IC50 of 4.2 nM for HeLa cells[1]. microtubule[1]

[1]. Li J, et al. Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers. J Am Chem Soc. 2011 Nov 30;133(47):19064-7.