Tubulysin D

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Tubulysin D

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

309935-57-7

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品介绍

Tubulysin D 是从粘细菌 Archangium geophyra 和 Angiococcus disciformis 中分离的微管溶素中最有效的衍生物。 Tubulysin D 是一种新型四肽，通过抑制微管蛋白聚合而显示出有效的抗肿瘤活性并导致细胞周期停滞和凋亡，IC50 为 1.7 μM。 Tubulysin 在哺乳动物细胞中显示出极其有效的细胞毒活性，包括多药耐药细胞系。

Cas No.	309935-57-7
别名	微管蛋白抑制剂 D
Canonical SMILES	CC(O[C@@H](C1=NC(C(N[C@H](C[C@H](C)C(O)=O)CC2=CC=CC=C2)=O)=CS1)C[C@H](C(C)C)N(COC(CC(C)C)=O)C([C@@]([C@@H](C)CC)([H])NC([C@@H](CCCC3)N3C)=O)=O)=O
分子式	C₄₃H₆₅N₅O₉S
分子量	828.07
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Tubulysin D is one of the most potent derivatives among the tubulysins isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin D is a novel tetrapeptide that displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1.7 μM[1]. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[2]. IC50: 1.7 μM (Tubulin)[1] Tubulysin D has IC50s of 4.7 pM, 3.1 pM, 670 pM and 13 pM for HL60, HCT116, MCF7, A549 cell lines antiproliferative activity, respectively[1]. [1]. Shibue T, et al. Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline. Bioorg Med Chem Lett. 2011 Jan 1;21(1):431-4. [2]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12.