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Tubulysin F
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tubulysin F图片
CAS NO:368870-67-1
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Tubulysin F 是一种高度细胞毒性的肽,是从粘细菌 Archangium geophyra 和 Angiococcus disciformis 中分离的。 Tubulysin 在哺乳动物细胞中显示出极其有效的细胞毒活性,包括多药耐药细胞系,IC50 值在较低的纳摩尔范围内。 Tubulysin F 是一种具有细胞毒性活性微管溶素,抑制微管蛋白聚合并导致细胞周期停滞和凋亡。
Cas No.368870-67-1
别名微管蛋白抑制剂 F
Canonical SMILESO=C([C@@H]1N(CCCC1)C)N[C@]([C@@H](C)CC)([H])C(N(COC(CC)=O)[C@@H](C(C)C)C[C@H](C2=NC(C(N[C@H](C[C@H](C)C(O)=O)CC3=CC=CC=C3)=O)=CS2)OC(C)=O)=O
分子式C41H61N5O9S
分子量800.02
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tubulysin F is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[1]. Tubulysin F is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].

[1]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12. [2]. Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.