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Alloxan(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alloxan(hydrate)图片
CAS NO:2244-11-3
包装与价格:
包装价格(元)
5g电议
10g电议

产品介绍
 
Cas No.2244-11-3
别名阿脲 一水合物
Canonical SMILESO=C(C(C(N1)=O)=O)NC1=O.O
分子式C4H2N2O4.H2O
分子量160.1
溶解度DMF: 5 mg/ml,DMSO: 5 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Alloxan is a toxin that selectively eliminates pancreatic β-cells in mice, rats, and certain other animals, and is used to model type 1 diabetes in humans.1 Reduction of alloxan within β-cells precedes the generation of reactive oxygen species, which in turn contribute to β-cell death.2 The dose of alloxan needed to destroy beta cells, and thus induce diabetes, depends on the animal species, route of administration, and nutritional status.2,3,4

References
1. Dunn, J.S., Duffy, E., Gilmour, M.K., et al. Further observations on the effects of alloxan on the pancreatic islets. Journal of Physiology 103(2), 233-243 (1944).
2. Szkudelski, T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol. Res. 50(6), 537-546 (2001).
3. Eizirik, D.L., Pipeleers, D.G., Ling, Z., et al. Major species differences between humans and rodents in the susceptibility to pancreatic β-cell injury. Proceedings of the National Academy of Sciences of the United States of America 91(20), 9253-9256 (1994).
4. Tyberg, B., Andersson, A., and Borg, L.A. Species differences in susceptibility of transplanted and cultured pancreatic islets to the β-cell toxin alloxan. General and Comparative Endocrinology 122, 238-251 (2001).