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ISPA-28
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ISPA-28图片
CAS NO:1006335-39-2
包装:5mg
市场价:3060元

产品介绍
ISPA-28 是特异性的疟原虫表面阴离子通道 (PSAC) 拮抗剂。ISPA-28 直接可逆的与CLAG3 结合。
Cas No.1006335-39-2
分子式C21H24N6O3
分子量408.45
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ISPA-28 is a specific plasmodial surface anion channel (PSAC) antagonist. ISPA-28 binds directly and reversibly to CLAG3[1][2].

ISPA-28 is only effective as an inhibitor of Dd2 channels (K0.5 values of 56 nM and 43 μM for Dd2 and HB3 channels, respectively)[2].

[1]. Sanjay A Desai, et al. Ion and Nutrient Uptake by Malaria Parasite-Infected Erythrocytes.
[2]. Wang Nguitragool, et al. Proteolysis at a Specific Extracellular Residue Implicates Integral Membrane CLAG3 in Malaria Parasite Nutrient Channels.