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GS-441524 tris-isobutyryl ester
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
GS-441524 tris-isobutyryl ester图片
CAS NO:2563617-99-0
包装与价格：
包装价格(元)
500 µg电议
1mg电议

产品介绍
A prodrug form of GS-441524
Cas No.2563617-99-0
Canonical SMILESO=C(C(C)C)OC[C@@H]1[C@@H](OC(C(C)C)=O)[C@@H](OC(C(C)C)=O)[C@@](C#N)(C2=CC=C3N2N=CN=C3N)O1
分子式C24H31N5O7
分子量501.5
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GS-441524tris-isobutyryl ester is a prodrug form of the antiviral nucleoside analog and remdesivir metabolite GS-441524 .1It reduces the cytopathic effect of respiratory syncytial virus (RSV) in infected HEp-2 cells with an EC50value of 0.26 µM.

1.Mackman, R.L., Hui, H.C., Perron, M., et al.Prodrugs of a 1’-CN-4-aza-7,9-dideazaadenosine C-nucleoside leading to the discovery of remdesivir (GS-5734) as a potent inhibitor of respiratory syncytial virus with efficacy in the african green monkey model of RSVJ. Med. Chem.64(8)5001-5017(2021)