CL2A-SN-38

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CL2A-SN-38

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1279680-68-0

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议

产品介绍

CL2A-SN-38是drug-linkerconjugate，由linkerCL2A和毒性分子SN-38连接而成的，可用来制备抗体偶联药物。CL2A-SN-38针对人类实体瘤表现出特异性的抗肿瘤作用。SN-38是一种DNATopoisomeraseI抑制剂。CL2A是一种不可降解(non-cleavable)的含PEG8-和三偶氮的PBC-肽-mclinker。CL2A通过pH敏感性降解，产生旁观者效应，并通过二硫键与抗体结合在半胱氨酸残基上。

Cas No.	1279680-68-0
Canonical SMILES	O=C(O[C@](C1=C(CO2)C(N3CC4=C(CC)C5=CC(O)=CC=C5N=C4C3=C1)=O)(CC)C2=O)OCC6=CC=C(NC([C@H](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7N=NC(CNC(C8CCC(CN9C(C=CC9=O)=O)CC8)=O)=C7)=O)=O)=O)C=C6
分子式	C₇₃H₉₇N₁₁O₂₂
分子量	1480.61
溶解度	DMSO: 100 mg/mL (67.54 mM)
储存条件	-20℃, stored under nitrogen, away from moisture
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a nonclaevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond[1]. [1]. Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.