| CAS NO: | 622795-76-0 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
PIP-199是一种RecQ介导的基因组不稳定蛋白RMI核心复合物/MM2相互作用(RMIcorecomplex/MM2interaction)的选择性抑制剂，其IC50值为36μM。MM2是FANCM上RMI复合物的结合位点。PIP-199可用于耐受肿瘤对DNA交联化疗药物的增敏研究。
| Cas No. | 622795-76-0 |
| Canonical SMILES | O=C(N1CCN(C(C2=C(C3=CC=CC=C3)N(O)C4=C2C=CC=C4)C5=NC=CC=C5)CC1)OCC |
| 分子式 | C27H28N4O3 |
| 分子量 | 456.54 |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. MM2 is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM). PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics[1]. Induction of the Fanconi anemia (FA) DNA repair pathway is a common mechanism by which tumors evolve resistance to DNA crosslinking chemotherapies[1].Proper execution of the FA pathway requires interaction between the FANCM and the RMI complex, and mutations that disrupt FANCM/RMI interactions sensitize cells to DNA crosslinking agents[1]. [1]. Andrew F. Voter, et al. A high throughput screening strategy to identify protein-protein interaction inhibitors that block the Fanconi anemia DNA repair pathway. J Biomol Screen. 2016 Jul; 21(6): 626-633. |
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