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ARN24139
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ARN24139图片
CAS NO:2699768-78-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A topoisomerase II poison
Cas No.2699768-78-8
Canonical SMILESS=C(N1C2=CC=CC=C2)N(C3=CC=CC=C3)C(O)=C(C(NC4=CC(OC(F)(F)F)=CC=C4)=O)C1=O
分子式C24H16F3N3O4S
分子量499.5
溶解度DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml,DMSO: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ARN24139 is a topoisomerase II poison (IC50= 7.3 µM in a topoisomerase II decatenation assay).1It inhibits proliferation of DU145, HeLa, and A549 cells (IC50s = 4.7, 3.8, and 3.1 µM, respectively).

1.Arencibia, J.M., Brindani, N., Franco-Ulloa, S., et al.Design, synthesis, dynamic docking, biochemical characterization, and in vivo pharmacokinetics studies of novel topoisomerase II poisons with promising antiproliferative activityJ. Med. Chem.63(7)3508-3521(2020)