| CAS NO: | 2141978-86-9 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 2141978-86-9 |
| Canonical SMILES | O=C(C1=CC=CC=C1)N/C(C(N2CCC(C3=CC=C(C=C3)Br)(CC2)O)=O)=C\C4=CC=CC=C4 |
| 分子式 | C27H25BrN2O3 |
| 分子量 | 505.4 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | K22 is an antiviral agent.1It inhibits the replication of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), human coronavirus 229E (HCoV-229E), feline coronavirus (FCoV), and mouse hepatitis virus (MHV) in Vero cells when used at a concentration of 40 µM. K22 inhibits the formation of double membrane vesicles, a hallmark of coronavirus replication, and inhibits viral RNA synthesis in HCoV-229E-infected MRC-5 cells. It also reduces viral titers in cells infected with variousArteriviridaeorTorovirinaeviruses.2 1.Lundin, A., Dijkman, R., BergstrÖm, T., et al.Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the Middle East respiratory syndrome virusPLoS Pathog.10(5)e1004166(2014) 2.Rappe, J.C.F., de Wilde, A., Di, H., et al.Antiviral activity of K22 against members of the order NidoviralesVirus Res.24628-34(2018) |
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