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Temozolomide-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Temozolomide-d3图片
CAS NO:208107-14-6
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议

产品介绍
替莫唑胺-d3 (NSC 362856-d3) 是氘标记的替莫唑胺。替莫唑胺 (NSC 362856) 是一种口服活性 DNA 烷化剂,可穿过血脑屏障。替莫唑胺也是一种促自噬和促凋亡剂。替莫唑胺可有效对抗以低水平的 O6-烷基鸟嘌呤 DNA 烷基转移酶 (OGAT) 和功能性错配修复系统为特征的肿瘤细胞。替莫唑胺具有抗肿瘤和抗血管生成作用。
Cas No.208107-14-6
别名替莫唑胺 d3
Canonical SMILESO=C(N(C([2H])([2H])[2H])N=N1)N2C1=C(C(N)=O)N=C2
分子式C6H3D3N6O2
分子量197.2
溶解度DMF: 5 mg/ml,DMSO: 5 mg/ml,PBS (pH 7.2): 0.33 mg/ml
储存条件Store at 2°C to 8°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Temozolomide-d3(TMZ-d3) contains three deuterium atoms located on the methyl group. It is intended for use as an internal standard for the quantification of temozolomide by GC- or LC-MS. TMZ is an imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells.1TMZ is rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier.1Formulations containing TMZ are effective in a variety of types of cancer, including aggressive brain cancers.1,2,3

1.Marchesi, F., Turriziani, M., Tortorelli, G., et al.Triazene compounds: Mechanism of action and related DNA repair systemsPharmacol. Res.56(4)275-287(2007) 2.Khan, O.A., Ranson, M., Michael, M., et al.A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancerBr. J. Cancer98(10)1614-1618(2008) 3.Daniel, R.A., Rozanska, A.L., Mulligan, E.A., et al.Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699Br. J. Cancer103(10)1588-1596(2010)