BAY 707 是一种底物竞争性、高效和选择性的 MTH1(NUDT1) 抑制剂，IC50 为 2.3 nM。 BAY 707 与其他 MTH1 化合物相比具有良好的药代动力学 (PK) 特征，并且在小鼠中具有良好的耐受性，但明显缺乏体外或体内抗癌功效。
| Cas No. | 2109805-96-9 |
| Canonical SMILES | CCNC(C1=CC2=C(N3CCOC[C@@H]3C)C=CN=C2N1)=O |
| 分子式 | C15H20N4O2 |
| 分子量 | 288.34 |
| 溶解度 | DMSO|28.83|100|ethanol|2.88|10| |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potent and selective MTH1 inhibitor (IC50 = 2.3 nM). Exhibits no significant activity at 1 μM concentration against a panel of 97 kinases. Cell-permeable and active in vivo. Displays no antitumor activity in vitro or in vivo. |
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