| CAS NO: | 33430-62-5 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 1g | 电议 |
| Cas No. | 33430-62-5 |
| 别名 | 胸苷酸二钠 |
| Canonical SMILES | O=C(N1)C(C)=CN([C@@]2([H])C[C@H](O)[C@@H](COP([O-])([O-])=O)O2)C1=O.[Na+].[Na+] |
| 分子式 | C10H13N2O8P•2Na |
| 分子量 | 366.2 |
| 溶解度 | PBS (pH 7.2): slightly soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 5'-Thymidylic acid (dTMP) is a deoxyribonucleotide.1It is formedviamethylation of dUMP by thymidylate synthase. It is further phosphorylated by thymidine kinase (TK) to form dTDP during nucleic acid synthesis.2Oral administration of dTMP in combination with dCMP increases lifespan in aTk2 H126Nknock-in mouse model of TK2 deficiency.3 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide BiosynthesisBiochemistry(2002) 2.Lee, L.S., and Cheng, Y.Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemiaJ. Biol. Chem.252(16)5686-5691(1977) 3.Lopez-Gomez, C., Levy, R.J., Sanchez-Quintero, M.J., et al.Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiencyAnn. Neurol.81(5)641-652(2017) |
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