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T-705RTP sodium
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
T-705RTP sodium图片
CAS NO:356783-10-3
包装:1mg

产品介绍

T-705RTPsodium是一种具有具有选择性和GTP竞争性的流感病毒RNA聚合酶(RNApolymerase)抑制剂，IC50为0.14μM，Ki为1.52μM。T-705RTPsodium是T-705的活性三磷酸盐代谢产物，具有有效的抗流感病毒活性。

Cas No.356783-10-3
Canonical SMILESO[C@H]1[C@H](N2C(C(C(N)=O)=NC(F)=C2)=O)O[C@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)[C@H]1O
分子式C10H12FN3Na3O15P3
分子量595.1
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

T-705RTP sodium is a selective and GTP-competitive influenza virus RNA polymerase inhibitor with an IC50 of 0.14 μM and a Ki of 1.52 μM. T-705RTP sodium is the active triphosphate metabolite of T-705 and has potent anti-influenza virus activity[1][2].

T-705RTP sodium and T-705RMP are detected in MDCK cells treated with T-705. T-705RTP sodium inhibits influenza virus RNA polymerase activity in a dose-dependent and a GTP-competitive manner[1]. T-705RTP sodium inhibits the incorporation of ATP and GTP in a competitive manner with Ki values of 7.72 and 1.56 μM, respectively. T-705RTP sodium inhibits the incorporation of CTP in a mixed-type manner with a Ki value of 11.3 μM, and also inhibits the incorporation of UTP in a noncompetitive manner[2]. The incorporation of a single molecule of T-705RTP sodium (10-1000 μM) inhibits influenza virus RNA strand extension[2].

[1]. Furuta Y, et al. Mechanism of action of T-705 against influenza virus. Antimicrob Agents Chemother. 2005 Mar;49(3):981-6. [2]. Sangawa H, et al. Mechanism of action of T-705 ribosyl triphosphate against influenza virus RNA polymerase. Antimicrob Agents Chemother. 2013 Nov;57(11):5202-8.