Syk Inhibitor 是一种生物可利用的、细胞可渗透的 Syk 抑制剂，EC50 为 313 nM，IC50 为 14 nM。
| Cas No. | 622387-85-3 |
| Canonical SMILES | [H]N(C1=C(/C2=C/C3=CN(C)C4=C3C=CC=C4)C=C(S(=O)(N)=O)C=C1)C2=O |
| 分子式 | C18H15N3O3S |
| 分子量 | 353.4 |
| 溶解度 | DMSO: 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 5 nM and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 1.4 μM). At 2 μM, this compound completely abolishes convulxin-induced platelet aggregation and shape change. |
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