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LOXO-292
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LOXO-292图片
CAS NO:2152628-33-4
包装与价格:
包装价格(元)
2mg电议
5mg电议
25mg电议
100mg电议

产品介绍
LOXO-292 (LOXO-292) 是一种有效的选择性 RET 激酶抑制剂,对 RET (WT)、RET (V804M) 和 RET (G810R) 的 IC50 值分别为 14.0 nM、24.1 nM 和 530.7 nM。 LOXO-292 具有抗癌活性。
Cas No.2152628-33-4
别名塞尔帕替尼; LOXO-292
化学名6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
分子式C29H31N7O3
分子量525.613
溶解度DMF: 1 mg/ml,DMSO: 1 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LOXO-292 (Selpercatinib, LOXO 292, LOXO292) is a potent, selective, orally availableRET kinaseinhibitor with potential antineoplastic activity; displays >100-fold selectivity versus important off-targets; shows anti-tumor activty in the brain and periphery in RET-dependent tumor models in vivo.Lung Cancer

Reference:
[1]. Subbiah V, et al. Ann Oncol. 2018 Aug 1;29(8):1869-1876.
[2]. Cancer Discov. 2018 Aug;8(8):904-905.