| CAS NO: | 54-31-9 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
| Cas No. | 54-31-9 |
| 别名 | 呋塞米 |
| 化学名 | 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid |
| Canonical SMILES | C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl |
| 分子式 | C12H11ClN2O5S |
| 分子量 | 330.74 |
| 溶解度 | ≥ 14.9mg/mL in DMSO |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Furosemide is an inhibitor of Na+/2Cl-/K+ cotransporter [1]. The Na-K-Cl cotransporter (NKCC) is a protein that acts as an active transporter helping sodium, potassium, and chloride into and out of cells. NKCC1 has important functions in organs that secrete fluids. NKCC2 exists in the kidney and serves to extract sodium, potassium, and chloride from the urine [2]. Furosemide is an antagonist of Na+/2Cl-/K+ cotransporter. In adult brain tissue, furosemide blocked the epileptiform activity through inhibiting cell swelling, which was concomitant with its inhibition of activity-driven changes of the extracellular space (ECS) [1]. Furosemide inhibited the production and release of cytokines IL-6, IL-8, and TNF-ɑ from peripheral mononuclear cells and exhibited an anti-inflammatory effect [3]. In patients with liver cirrhosis, furosemide inhibited the natriuretic effect and increased the levels of atrial natriuretic factor (ANF) and circulating endothelin. In neonates, furosemide significantly increased the urinary excretion of aldosterone and endothelin-1 [3]. References: |
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