| CAS NO: | 36507-30-9 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 36507-30-9 |
| 别名 | 卡马西平10,11-环氧化物 |
| Canonical SMILES | O=C(N1C2=C(C3OC3C4=C1C=CC=C4)C=CC=C2)N |
| 分子式 | C15H12N2O2 |
| 分子量 | 252.3 |
| 溶解度 | DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 1 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.1,2It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells expressing CYP3A4 or CYP2C8, respectively.1Carbamazepine 10,11-epoxide has anticonvulsant activity against maximal electroshock-induced seizures in mice.2It has been found in wastewater effluent.3 1.Kerr, B.M., Thummel, K.E., Wurden, C.J., et al.Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formationBiochem. Pharmacol.47(11)1969-1979(1994) 2.Bourgeois, B.F., and Wad, N.Individual and combined antiepileptic and neurotoxic activity of carbamazepine and carbamazepine-10,11-epoxide in miceJ. Pharmacol. Exp. Ther.231(2)411-415(1984) 3.Miao, X.-S., Yang, J.-J., and Metcalfe, C.D.Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plantEnviron. Sci. Technol.39(19)7469-7475(2005) |
m.cnreagent.com