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Colupulone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Colupulone图片
CAS NO:468-27-9
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
A β-acid with diverse biological activities
Cas No.468-27-9
别名类蛇麻酮
Canonical SMILESO=C(C(C)C)C(C(O)=C1C/C=C(C)\C)=C(O)C(C/C=C(C)\C)(C/C=C(C)\C)C1=O
分子式C25H36O4
分子量400.6
溶解度DMSO: soluble,Methanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Colupulone is a β-acid that has been found inH. lupulusand has diverse biological activities.1,2,3It activates the pregnane X receptor (PXR) in a reporter assay when used at concentrations of 1, 3, and 10 µM.1Dietary administration of colupulone (0.18% w/w) induces hepatic cytochrome P450 (CYP) isoform 3A (CYP3A) activity in mice.2It also decreases serum glucose levels in non-diabetic mice and increases serum glucose levels indb/dbmice.3

1.Teotico, D.G., Bischof, J.J., Peng, L., et al.Structural basis of human pregnane X receptor activation by the hops constituent colupuloneMol. Pharmacol.74(6)1512-1520(2008) 2.Mannering, G.J., Shoeman, J.A., and Deloria, L.B.Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouseDrug Metab. Dispos.20(2)142-147(1992) 3.Mannering, G.J., Shoeman, J.A., and Shoeman, D.W.Effects of colupulone, a component of hops and brewers yeast, and chromium on glucose tolerance and hepatic cytochrome P450 in nondiabetic and spontaneously diabetic miceBiochem. Biophys. Res. Commun.200(3)1455-1462(1994)