CAS NO: | 468-27-9 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
Cas No. | 468-27-9 |
别名 | 类蛇麻酮 |
Canonical SMILES | O=C(C(C)C)C(C(O)=C1C/C=C(C)\C)=C(O)C(C/C=C(C)\C)(C/C=C(C)\C)C1=O |
分子式 | C25H36O4 |
分子量 | 400.6 |
溶解度 | DMSO: soluble,Methanol: soluble |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Colupulone is a β-acid that has been found inH. lupulusand has diverse biological activities.1,2,3It activates the pregnane X receptor (PXR) in a reporter assay when used at concentrations of 1, 3, and 10 µM.1Dietary administration of colupulone (0.18% w/w) induces hepatic cytochrome P450 (CYP) isoform 3A (CYP3A) activity in mice.2It also decreases serum glucose levels in non-diabetic mice and increases serum glucose levels indb/dbmice.3 1.Teotico, D.G., Bischof, J.J., Peng, L., et al.Structural basis of human pregnane X receptor activation by the hops constituent colupuloneMol. Pharmacol.74(6)1512-1520(2008) 2.Mannering, G.J., Shoeman, J.A., and Deloria, L.B.Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouseDrug Metab. Dispos.20(2)142-147(1992) 3.Mannering, G.J., Shoeman, J.A., and Shoeman, D.W.Effects of colupulone, a component of hops and brewers yeast, and chromium on glucose tolerance and hepatic cytochrome P450 in nondiabetic and spontaneously diabetic miceBiochem. Biophys. Res. Commun.200(3)1455-1462(1994) |