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Desmethyl Bosentan
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Desmethyl Bosentan图片
CAS NO:253688-61-8
包装与价格：
包装价格(元)
500 µg电议
1mg电议
5mg电议

产品介绍
An active metabolite of bosentan
Cas No.253688-61-8
别名波生坦O-去甲基杂质
Canonical SMILESO=S(NC1=NC(C2=NC=CC=N2)=NC(OCCO)=C1OC3=C(O)C=CC=C3)(C4=CC=C(C(C)(C)C)C=C4)=O
分子式C26H27N5O6S
分子量537.6
溶解度Acetonitrile: soluble,DMSO: soluble,Methanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan .1Desmethyl bosentan (25 µM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay.

1.van Giersbergen, P.L.M., Gnerre, C., Treiber, A., et al.Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptorBr. J. Clin. Pharmacol.54(5)561-562(2002)