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Indapamide-13C-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Indapamide-13C-d3图片
包装与价格:
包装价格(元)
500 µg电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of indapamide
Canonical SMILESClC1=C(S(N)(=O)=O)C=C(C(NN2C([13C]([2H])([2H])[2H])CC3=C2C=CC=C3)=O)C=C1
分子式C15[13C]H13D3ClN3O3S
分子量369.8
溶解度Acetonitrile: soluble,DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Indapamide-13C-d3is intended for use as an internal standard for the quantification of indapamide by GC- or LC-MS. Indapamide is a carbonic anhydrase (CA) inhibitor (Kis = 0.23, 36, 10, and 13 nM for CAVII, CAIX, CAXII, and CAXIII, respectively).1It is selective for these CAs over CAI-CAVI and CAXIV (Kis = 213->10,000 nM). Indapamide is a thiazide-like diuretic that reduces blood pressure in spontaneously hypertensive rats (SHRs).2It also increases urinary and renovascular levels of 11,12-EET and 14,15-EET, decreases urinary levels of 11,12-DiHET and 14,15-DiHET, and reduces renal cortical malondialdehyde levels in SHRs. Formulations containing indapamide have been used in the treatment of hypertension, as well as salt and fluid retention associated with congestive heart failure.

1.Temperini, C., Cecchi, A., Scozzafava, A., et al.Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: When three water molecules and the keto-enol tautomerism make the differenceJ. Med. Chem.52(2)322-328(2019) 2.Ma, F., Lin, F., Chen, C., et al.Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidneyMol. Pharmacol.84(2)286-295(2013)