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rac-Desethyl Oxybutynin(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
rac-Desethyl Oxybutynin(hydrochloride)图片
CAS NO:81039-77-2
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An active metabolite of oxybutynin
Cas No.81039-77-2
Canonical SMILESO=C(C(C1CCCCC1)(C2=CC=CC=C2)O)OCC#CCNCC.Cl
分子式C20H27NO3·HCl
分子量365.9
溶解度Chloroform: slightly soluble,Methanol: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

rac-Desethyl oxybutynin is an active metabolite of the muscarinic acetylcholine receptor (mAChR) antagonist oxybutynin .1,2,3rac-Desethyl oxybutynin is formed from oxybutynin by the cytochrome P450 (CYP) isoform CYP3A4.2It binds to mAChRs in isolated rat bladder, submaxillary gland, heart, and colon with Kivalues of 5.38, 3.12, 16, and 5.59 nM, respectively.rac-Desethyl oxybutynin (0.4 and 0.8 mg/kg) reduces micturition pressure in rats.3

1.Lindeke, B., HallstrÖm, G., Johansson, C., et al.Metabolism of Oxybutynin: Establishment of desethyloxybutynin and oxybutynin N-oxide formation in rat liver preparation using deuterium substitution and gas chromatographic mass spectrometric analysisBiomed. Mass Spectrom.8(10)506-513(1981) 2.Oki, T., Kawashima, A., Uchida, M., et al.In vivo demonstration of muscarinic receptor binding activity of N-desethyl-oxybutynin, active metabolite of oxybutyninLife Sci.76(21)2445-2456(2005) 3.Mizushima, H., Kinoshita, K., Abe, K., et al.Pharmacokinetics/pharmacodynamics analysis of the relationship between the in vivo micturition pressure and receptor occupancy of (R)-oxybutynin and its metabolite in ratsBiol. Pharm. Bull.30(5)955-962(2007)