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dBET57
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
dBET57图片
CAS NO:1883863-52-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
dBET57 是一种有效选择性的 BRD4BD1 降解剂,基于 PROTAC 技术。dBET57 介导了 E3 泛素连接酶 CRL4CRBN 的招募,对 BRD4BD1 作用的 DC50/5h 值为 500 nM,对 BRD4BD2 不起作用。
Cas No.1883863-52-2
Canonical SMILESO=C(NCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4
分子式C34H31ClN8O5S
分子量699.18
溶解度DMSO: 250 mg/mL (357.56 mM)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

dBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology. dBET57 mediates recruitment to the CRL4CRBN E3 ubiquitin ligase, with a DC50/5h of 500 nM for BRD4BD1, and is inactive on BRD4BD2[1]. BRD4 (BD1)|500 nM (DC50)

[1]. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714.