CAS NO: | 108181-00-6 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
Cas No. | 108181-00-6 |
Canonical SMILES | O=C(OCC)C1=[N+]2C(C(C=CC=C3)=C3CC2)=CC4=C1C(C=CC=C5)=C5C6=C4C=CC=C6 |
分子式 | C28H22NO2+ |
分子量 | 404.48 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC50=21 μM), PRMT6 (IC50= 47μM), and PRMT5[1]. IC50: 1.8 μM (CARM1)[1] DC_C66 (6.25-100 μM; 24-72 hours) exhibits antiproliferation activity in several CARM1-associated cancer cell lines[1]. Cell Proliferation Assay[1] Cell Line: HELA, K562, MCF7 cells [1]. Ye F, et al. Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays. Biomed Res Int. 2016;2016:7086390. |