CAS NO: | 2369607-62-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
Cas No. | 2369607-62-3 |
Canonical SMILES | O=C1C2=CC=NC(N3C=C(CCN4CCC5(CCC6=C5C=CC=C6)CC4)C=N3)=C2N=CN1 |
分子式 | C25H26N6O |
分子量 | 426.51 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | KDM4-IN-2 (Compound 19a) is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7?nM for KDM4A and KDM5B, respectively[1]. Ki: 4 nM (KDM4A ), 7?nM (KDM5B)[1]IC50: 100±41 nM (KDM4A), 43±21 nM (KDM4B), 38 nM (KDM5B), 123 nM (KDM5C), 4.50 μM (KDM2A), 5.78 μM (KDM3A), 90.22?μM (KDM6B)[1] [1]. Le Bihan YV, et al. C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Eur J Med Chem. 2019 Sep 1;177:316-337. |