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KDM4-IN-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KDM4-IN-2图片
CAS NO:2369607-62-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
KDM4-IN-2 (Compound 19a) 是一种有效的选择性 KDM4/KDM5 双重抑制剂,Ki 分别为 4 nM 和 7 nM。
Cas No.2369607-62-3
Canonical SMILESO=C1C2=CC=NC(N3C=C(CCN4CCC5(CCC6=C5C=CC=C6)CC4)C=N3)=C2N=CN1
分子式C25H26N6O
分子量426.51
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

KDM4-IN-2 (Compound 19a) is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7?nM for KDM4A and KDM5B, respectively[1]. Ki: 4 nM (KDM4A ), 7?nM (KDM5B)[1]IC50: 100±41 nM (KDM4A), 43±21 nM (KDM4B), 38 nM (KDM5B), 123 nM (KDM5C), 4.50 μM (KDM2A), 5.78 μM (KDM3A), 90.22?μM (KDM6B)[1]

[1]. Le Bihan YV, et al. C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Eur J Med Chem. 2019 Sep 1;177:316-337.