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MS023 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MS023 dihydrochloride图片
CAS NO:1992047-64-9
包装与价格:
包装价格(元)
Free Sample (0.1-0.5mg)电议
10mM (in 1mL DMSO)电议
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
MS023 dihydrochloride 是一种有效选择性的,具有细胞活性的人 I 型蛋白精氨酸甲基转移酶 (PRMTs) 抑制剂,对 PRMT1,PRMT3,PRMT4,PRMT6 和 PRMT8 的 IC50 分别为 30,119,83,4 和 5 nM。
Cas No.1992047-64-9
Canonical SMILESCC(OC1=CC=C(C=C1)C2=CNC=C2CN(C)CCN)C.Cl.Cl
分子式C17H27Cl2N3O
分子量360.32
溶解度DMSO: ≥ 150 mg/mL (416.30 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1]. IC50: 30 nM (PRMT1), 119 nM (PRMT3), 83 nM (PRMT4), 4 nM (PRMT6), 5 nM (PRMT8)[1]

MS023 (1-1000 nM; 48 hours) inhibits PRMT1 methyltransferase activity in MCF7 cells[1]. MS023(1-1000 nM; 20 hours) inhibits PRMT6 methyltransferase activity in HEK293 cells[1]. Western Blot Analysis[1] Cell Line: MCF7 and HEK293 cells

[1]. Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81.