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NMS-P515
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NMS-P515图片
CAS NO:1262395-13-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
NMS-P515 是有效的、口服有效的、立体定向的PARP-1 的抑制剂,Kd 值为16 nM,IC50 值为 27 nM (Hela 细胞中)。有抗肿瘤活性。
Cas No.1262395-13-0
Canonical SMILESO=C(N)C1=C2C([C@H](C)N(C3CCN(C4CCCCC4)CC3)C2=O)=CC=C1
分子式C21H29N3O2
分子量355.47
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a Kd of 16 nM and an IC50 of 27 nM (in Hela cells). Anti-tumor activity[1]. PARP-1|16 nM (Kd)|PARP-1|27 nM (IC50, in Hela cells)

NMS-P515 (80 mg/kg, orally daily for 12 days) exhibits potent antitumor activity in mouse models based pancreatic cancer[1]. Animal Model: Subcutaneously implanted Capan-1 pancreatic (BRCA2-mutated) mouse xenografts[1].

[1]. Papeo G, et al. Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515. ACS Med Chem Lett. 2019 Mar 13;10(4):534-538.