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Procyanidin B3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Procyanidin B3图片
CAS NO:23567-23-9
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Procyanidin B3 是一种天然产物,为组蛋白乙酰转移酶 (HAT) 特异性抑制剂,可与 p300 的其他位点而非活性位点结合,选择性地抑制 p300 介导的 androgen 受体乙酰化。Procyanidin B3 对 HDAC 或 组蛋白甲基转移酶 (HMT) 无作用。
Cas No.23567-23-9
别名原花青素 B3
Canonical SMILESO[C@@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3[C@H]1C4=C5C(C[C@H](O)[C@@H](C6=CC=C(O)C(O)=C6)O5)=C(O)C=C4O
分子式C30H26O12
分子量578.52
溶解度DMSO: soluble,Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Procyanidin B3 is a natural product, acts as a specific HAT inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase)[1]. p300[1]

[1]. Choi KC, et al. Procyanidin B3, an inhibitor of histone acetyltransferase, enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor. Biochem J. 2011 Jan 1;433(1):235-44.