| CAS NO: | 120243-02-9 |
| 包装: | 1mg |
| 市场价: | 4763元 |
| Cas No. | 120243-02-9 |
| Canonical SMILES | OC1=C(O)C(C(N[C@H](CO)CCCCNC(C2=CC=CC(O)=C2O)=O)=O)=CC=C1 |
| 分子式 | C20H24N2O7 |
| 分子量 | 404.4 |
| 溶解度 | DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Myxochelin A is a microbial metabolite that has been found inA. disciformisand has diverse biological activities.1It is active against Gram-positive bacteria, includingB. cereus,S. aureus, andM. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 µg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC50value of 1.9 µM for the recombinant human enzyme.2It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 µg/ml.3 1.Kunze, B., Bedorf, N., Kohl, W., et al.Myxochelin A, a new iron-chelating compound from Angiococcus disciformis (Myxobacterales). Production, isolation, physico-chemical and biological propertiesJ. Antibiot. (Tokyo)42(1)14-17(1989) 2.Schieferdecker, S., KÖnig, S., Koeberle, A., et al.Myxochelins target human 5-lipoxygenaseJ. Nat. Prod.78(2)335-338(2015) 3.Miyanaga, S., Obata, T., Onaka, H., et al.Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861J. Antibiot. (Tokyo)59(11)698-703(2006) |
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