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Oleic Acid-d17
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Oleic Acid-d17图片
CAS NO:223487-44-3
包装与价格：
包装价格(元)
500 μg电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of oleic acid
Cas No.223487-44-3
别名cis-9-Octadecenoic Acid-d17
化学名9Z-octadecenoic-11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,18-d17 acid
Canonical SMILES[2H]C(C([2H])([2H])[2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])/C=C\CCCCCCCC(O)=O
分子式C18H17D17O2
分子量299.6
溶解度DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2):< 100μg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Oleic acid-d17contains 17 deuterium atoms at the 11, 11, 12, 12, 13, 13, 14, 14, 15, 15, 16, 16, 17, 17, 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of oleic acid by GC-or LC-mass spectrometry. Oleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. Oleic acid contributes about 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.1Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 &#181g/ml.1fMLF-induced neutrophil aggregation and degranulation is inhibited by 55% and 68%, respectively, using 5 &#181M oleic acid. This inhibition is comparable to that observed using arachidonic acid under the same conditions.2Oleic acid, whether applied extracellularly (EC50= ~60 &#181M) to human platelets or released from membrane phospholipids, causes an increase in intracellular calcium levels.3

1.Wahle, K.W., and Peacock, L.I.Effects of isomeric cis and trans eighteen carbon monounsaturated fatty acids on porcine platelet functionBiochim. Biophys. Acta1301(1-2)141-149(1996) 2.Naccache, P.H., Moiski, T.F., Volpi, M., et al.Modulation of rabbit neutrophil aggregation and degranulation by free fatty acidsJ. Leukoc. Biol.36(3)333-340(1984) 3.Siafaka-Kapadai, A., Hanahan, D.J., and Javors, M.A.Oleic acid-induced Ca2+ mobilization in human platelets: Is oleic acid an intracellular messengeroJ. Lipid Mediat. Cell Signal15(3)215-232(1997)