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QD-394
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
QD-394图片
CAS NO:2132411-21-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An inducer of ROS production
Cas No.2132411-21-1
Canonical SMILESO=C1C=C(C(C2=CN=CN=C12)=O)NC3=CC=C(N4CCN(CC4)C)C=C3
分子式C19H19N5O2
分子量349.4
溶解度DMF: 1 mg/lm,DMSO: 5 mg/ml,DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml,Ethanol: 1 mg/lm,PBS (pH 7.2): slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 µM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 µM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells.

1.Hu, S., Sechi, M., Singh, P.K., et al.A novel redox modulator induces a GPX4-mediated cell death that is dependent on iron and reactive oxygen speciesJ. Med. Chem.63(17)9838-9855(2020)