| CAS NO: | 108073-62-7 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 108073-62-7 |
| Canonical SMILES | OC1=C2C3=CC(OC)=CC=C3NC2=C(C)C(C)=C1OC |
| 分子式 | C16H17NO3 |
| 分子量 | 271.3 |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Carbazomycin C is a bacterial metabolite that has been found inStreptomycesand has diverse biological activities.1,2,3It is active againstS. aureus,B. anthracis,B. subtilis, andM. flavus(MICs = 50, 25, 100, and 50 µg/ml, respectively), the fungiT. asteroidesandT. mentagrophytes(MICs = 25 and 100 µg/ml, respectively), andP. falciparum(IC50= 2.1 µg/ml).2It is also active against a panel of five plant pathogenic fungi (MICs = 12.5-100 µg/ml).1Carbazomycin C is cytotoxic to MCF-7, KB, and NCI H187 cells (IC50s = 9.8, 21.4, and 8.2 µg/ml, respectively).2It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts (IC50= 1.9 µM).3 1.Naid, T., Kitahara, T., Kaneda, M., et al.Carbazomycins C, D, E and F, minor components of the carbazomycin complexJ. Antibiot. (Tokyo)40(2)157-164(1987) 2.Intaraudom, C., Rachtawee, P., Suvannakad, R., et al.Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924Tetrahedron67(39)7593-7597(2011) 3.Hook, D.J., Yacobucci, J.J., O'Connor, S., et al.Identification of the inhibitory activity of carbazomycins B and C against 5-lipoxygenase, a new activity for these compoundsJ. Antibiot. (Tokyo)43(10)1347-1348(1990) |
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