| CAS NO: | 16110-10-4 |
| 包装: | 5mg |
| 市场价: | 4770元 |
Acetaminophen glucuronide (APAP-glu) 是 Acetaminophen 的无活性葡萄糖醛酸代谢物。Acetaminophen 是一种选择性环氧合酶 2 (COX-2) 抑制剂，也是有效的肝 N-乙酰转移酶 2 (NAT2) 抑制剂。
| Cas No. | 16110-10-4 |
| 别名 | (4-乙酰氨基苯基)-葡糖苷酸,APAP-glu |
| 分子式 | C14H17NO8 |
| 分子量 | 327.29 |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen [1][2]. Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[3][4]. Acetaminophen is metabolized in the liver mainly by glucuronidation and sulfation, thus generating the nontoxic metabolites, Acetaminophen glucuronide (APAP-glu). Acetaminophen glucuronide is a substrate for both canalicular Mrp2 and basolateral Mrp3 in rodents[1]. [1]. Carolina I Ghanem, et al. Shift from biliary to urinary elimination of acetaminophen-glucuronide in acetaminophen-pretreated rats. J Pharmacol Exp Ther. 2005 Dec;315(3):987-95. [2]. Liudmila L Mazaleuskaya, et al. PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26. [3]. Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90. [4]. Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8(6):553-9. |
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