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Lasiocarpine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lasiocarpine图片
CAS NO:303-34-4
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Lasiocarpine 是一种有肝毒性吡咯里西定生物碱 ( hepatotoxic PA),在体内可引起致命的肝静脉闭塞性疾病。Lasiocarpine 只有在代谢转化为毒性中间体后才有毒性,包括 Dehydrolasiocarpine 和 N-oxide。
Cas No.303-34-4
别名毛果天芥菜碱
分子式C21H33NO7
分子量411.49
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide[1].

Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, known as dehydrolasiocarpine[1].Dehydrolasiocarpine and other putative didehydropyrrolizidine alkaloids (the pyrrolic esters) are very reactive,they attack nucleophilic macromolecules such as DNA and proteins, eliciting severe toxicities, including liver veno-occlusive disease and tumors[1].Lasiocarpine is mainly metabolized in vitro through five metabolic pathways, dehydrogenation, ester bond cleavage, demethylation[1].

[1]. Muluneh M Fashe, et al. Species-Specific Differences in the in Vitro Metabolism of Lasiocarpine. Chem Res Toxicol. 2015 Oct 19;28(10):2034-44.