CP21 is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio.¹It is active againstP. falciparumwhen used at concentrations of 10 and 100 µM.²CP21 inhibits production of prostaglandin I₂induced by epinephrine, arachidonic acid , or A23187 in isolated rat aortic rings with IC₅₀values of 1.3, 1.3, and 1.4 mM, respectively.³It inhibits glutamate-induced oxytosis, as well as decreases iodoacetic acid-induced cytotoxicity in anin vitromodel of ischemia, in HT22 mouse hippocampal cells (EC₅₀s = 13 and 9.5 µM, respectively).⁴CP21 (200 mg/kg) increases the excretion of iron, but not copper, zinc, calcium, or magnesium, in rabbits.⁵

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