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Chst15-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Chst15-IN-1图片
CAS NO:2158198-77-5
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Chst15-IN-1 是一种有效的可逆共价 Chst15 抑制剂。Chst15-IN-1 有效抑制 chondroitin sulfate-E (CS-E) 硫酸盐化水平和其他密切相关的 glycosaminoglycans (GAG) sulfotransferases。Chst15-IN-1 作为一种选择性sulfotransferase 抑制剂可以降低 chondroitin sulfate proteoglycans (CSPGs) 的抑制作用，并有希望用于刺激神经元修复。
Cas No.2158198-77-5
分子式C17H11BrCl2N2O3
分子量442.09
溶解度DMSO : 50 mg/mL (113.10 mM; ultrasonic and warming and heat to 60°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Chst15-IN-1 is a potent reversible covalentChst15inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely relatedglycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selectivesulfotransferaseinhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair[1].

Chst15-IN-1 (25 μM; 24 hours; Neu7 astrocytes) is selective for sulfotransferases over the myriad of reactive cysteine-containing proteins. Chst15-IN-1 (10 and 25 μM; Neu7 astrocytes) shows a significant dose dependent decrease in cell-surface CS-E expression[1].

Chst15-IN-1 (3.0 mg/kg; i.v.) has a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 hours[1].

Animal Model:Rats
Dosage:3.0 mg/kg (Pharmacokinetic Analysis)
Administration:I.v.
Result:Had a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 h.