| CAS NO: | 6989-98-6 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 10mg | 电议 |
D-Tubocurarinechloridepentahydrate是微管尿素的氯化物盐形式，是烟碱乙酰胆碱受体(AChR)的拮抗剂，可在手术或机械通气期间用作骨骼肌松弛剂。D-Tubocurarinechloridepentahydrate也是一种有效的神经肌肉阻滞剂。
| Cas No. | 6989-98-6 |
| 别名 | 氯化南美防己碱 |
| Canonical SMILES | COC1=C(OC2=CC(C[C@@]3([H])[N+](C)(C)CCC4=C3C(O5)=C(O)C(OC)=C4)=CC=C2O)C=C([C@]([H])(CC6=CC=C5C=C6)N(C)CC7)C7=C1.[H]Cl.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[Cl-] |
| 分子式 | C37H52Cl2N2O11 |
| 分子量 | 771.72 |
| 溶解度 | DMSO: 8.33 mg/mL (10.79 mM) |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | D-Tubocurarine chloride pentahydrate is the chloride salt form of Tubocurarine, a nicotinic acetylcholine receptors (AChR) antagonist, and can be used as a skeletal muscle relaxant during surgery or mechanical ventilation. D-Tubocurarine chloride pentahydrate is also a potent neuromuscular blocking agent[1][2][3]. Treatment of Caco-2 cells with the AChR antagonist Tubocurarine (10 µM) induces a disorganization of adherents junctions. Buffalo milk-derived products (MBCP) (18 µM) attenuates Tubocurarine AChR antagonist effects on Caco-2 cells adherens junctions[1]. [1]. Tenore GC, et al. Intestinal Anti-Inflammatory Effect of a Peptide Derived from Gastrointestinal Digestion of Buffalo (Bubalus bubalis) Mozzarella Cheese. Nutrients. 2019 Mar 13;11(3). pii: E610. [2]. Min CH, et al. The comparative effects of aminoglycoside antibiotics and muscle relaxants on electrical field stimulation response in rat bladder smooth muscle. Arch Pharm Res. 2016 Jun;39(6):863-70. [3]. P. W. Codding, et al. The crystal and molecular structure of a potent neuromuscular blocking agent: d-tubocurarine dichloride pentahydrate. Acta Cryst. (1973). B29, 935. |
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