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NS 383
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
NS 383图片
CAS NO:309711-59-9
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
NS 383 是一种有效且独特的选择性大鼠 ASIC 抑制剂，含有 1a 和/或 3 个亚基。
Cas No.309711-59-9
Canonical SMILESCCN1CCC2=C(C3=C(/C(C(N3)=O)=N\O)C=C2C4=CC=CC=C4)C1
分子式C19H19N3O2
分子量321.37
溶解度DMSO|1.61|5|
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.